Micek, H. M., Yang, N., Dutta, M., Rosenstock, L., Ma, Y., Hielsberg, C., McCord, M., Notbohm, J., McGregor, S., and Kreeger, P. K. The role of piezo1 mechanotransduction in high-grade serous ovarian cancer: Insights from an in vitro model of collective detachment. Sci Adv, 10(17):eadl4463, 2024. (link)
Nejad, M. R., Ruske, L. J., McCord, M., Zhang, J., Zhang, G., Notbohm, J., and Yeomans, J. M. Stress-shape misalignment in confluent cell layers. Nat Comm, 15(1):3628, 2024. (link)
Siegfreid, J., Crampton, A., Saghazadeh, S., Christensen, R., Notbohm, J., Bjork, J., and Baker, B. An integrative biology approach to understanding keratinocyte collective migration as stimulated by bioglass. Integr Biol, 16:zyae008, 2024. (link)
Sarkar, M., Burkel, B. M., Ponik, S. M., and Notbohm, J. Unexpected softening of a fibrous matrix by contracting inclusions. Acta Biomater, 177:253–264, 2024. (link)
Sarkar, M. and Notbohm, J. Bioinspired fiber networks with tunable mechanical properties by additive manufacturing. J Appl Mech, 90(8), 2023. (link)
Sarkar, M. and Notbohm, J. Evolution of force chains explains the onset of strain stiffening in fiber networks. J Appl Mech, 89(11):111008, 2022. (link)
Proestaki, M., Sarkar, M., Burkel, B. M., Ponik, S. M., and Notbohm, J. Effect of hyaluronic acid on microscale deformations of collagen gels. J Mech Behav Biomed, 135:105465, 2022. (link)
Sivagurunathan, S., Vahabikashi, A., Yang, H., Zhang, J., Vazquez, K., Rajasundaram, D., Politanska, Y., Abdala-Valencia, H., Notbohm, J., Guo, M., Adam, S. A., and Goldman, R. D. Expression of vimentin alters cell mechanics, cell-cell adhesion, and gene expression profiles suggesting the induction of a hybrid EMT in human mammary epithelial cells. Front Cell Dev Biol, 10:929495, 2022. (link)
Sarkar, M. and Notbohm, J. Quantification of errors in applying DIC to fiber networks imaged by confocal microscopy. Exp Mech, 62:1175–1189, 2022. (link)
Stempien, A., Josvai, M., de Lange,W. J., Hernandez, J. J., Notbohm, J., Kamp, T. J., Valdivia, H. H., Eckhardt, L. L., Maginot, K. R., Ralphe, J. C., and Crone, W. C. Identifying features of cardiac disease phenotypes based on mechanical function in a catecholaminergic polymorphic ventricular tachycardia model. Front Bioeng Biotechnol, 10:873531, 2022. (link)
Saraswathibhatla, A., Zhang, J., and Notbohm, J. Coordination of contractile tension and cell area changes in an epithelial cell monolayer. Phys Rev E, 105(2):024404, 2022. (link)
Vazquez, K., Saraswathibhatla, A., and Notbohm, J. Effect of substrate stiffness on friction in collective cell migration. Sci Rep, 12:2474, 2022. (link)
Saraswathibhatla, A., Henkes, S., Galles, E. E., Sknepnek, R., and Notbohm, J. Coordinated tractions increase the size of a collectively moving pack in a cell monolayer. Extreme Mech Lett, 48:101438, 2021. (link)
Proestaki, M., Burkel, B. M., Galles, E. E., Ponik, S. P., and Notbohm, J. Effect of Matrix Heterogeneity on Cell Mechanosensing. Soft Matter, 17:10263-10273, 2021. (link)
Zhang, J., Yang, N., Kreeger, P. K., and Notbohm, J. Topological defects in the mesothelium suppress ovarian cancer cell clearance. APL Bioeng, 5(3):036103, 2021. (link, press release)
Szulczewski, J. M., Inman, D. R., Proestaki, M., Notbohm, J., Burkel, B. M., and Ponik, S. M. Directional cues in the tumor microenvironment due to cell contraction against aligned collagen fibers. Acta Biomater, 129:96–109, 2021. (link)
Grekas, G., Proestaki, M., Rosakis, P., Notbohm, J., Makridakis, C., Ravichandran, G. Cells exploit a phase transition to establish interconnections in fibrous extracellular matrices. J R Soc Interface, 18:20200823, 2021 (link)
Saraswathibhatla, A., Galles, E. E., and Notbohm, J. Spatiotemporal force and motion in collective cell migration. Sci Data, 7:197, 2020. (link)
Saraswathibhatla, A. and Notbohm, J. Tractions and stress fibers control cell shape and rearrangements in collective cell migration. Phys Rev X, 10:011016, 2020. (link, press release)
Fleszar, A. J., Walker, A., Kreeger, P. K., and Notbohm, J. Substrate curvature induces fallopian tube epithelial cell invasion via cell-cell tension in a model of ovarian cortical inclusion cysts. Integr Biol, 11(8):342–352, 2019. (link)
Tyznik, S. and Notbohm, J. Length scale dependent elasticity in random three-dimensional fiber networks. Mech Mater, 138:103155, 2019. (link)
Spatarelu, C.-P., Zhang, H., Nguyen, D. T., Han, X., Liu, R., Guo, Q., Notbohm, J., Fan, J., Liu, L., and Chen, Z. Biomechanics of collective cell migration in cancer progression: Experimental and computational methods. ACS Biomater Sci Eng, 5:3766–3787, 2019. (link)
Proestaki, M., Ogren, A., Burkel, B., and Notbohm, J. Modulus of fibrous collagen at the length scale of a cell. Exp Mech, 2019. (link)
Rokhzan, R., Ghosh, C. C., Schaible, N., Notbohm, J., Yoshie, H., Ehrlicher, A. J., Higgins, S. J., Zhang, R., Haller, H., Hardin, C. C., David, S., Parikh, S. M., and Krishnan, R. Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function. Lab Invest, 99:138-145, 2019. (link)
Burkel, B., Proestaki, M., Tyznik, S., and Notbohm, J. Heterogeneity and nonaffinity of cell-induced matrix displacements. Phys Rev E, 98(5):052410, 2018. (link)
Kang, Y. G., Jang, H., Yang, T. D., Notbohm, J., Choi, Y., Park, Y., and Kim, B.-M. Quantification of focal adhesion dynamics of cell movement based on cell-induced collagen matrix deformation using second-harmonic generation microscopy. J Biomed Opt, 23(6):065001, 2018. (link)
Feng, D., Notbohm, J., Benjamin, A., He, S.,Wang, M., Ang, L.-H., Bantawa, M., Bouzid, M., Del Gado, E., Krishnan, R., and Pollak, M. R. Disease-causing mutation in a-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch. P Natl Acad Sci USA, 115(7):1517-1522, 2018. (link)
Grimmer, P. and Notbohm, J. Displacement propagation in fibrous networks due to local contraction. J Biomech Eng, 140:041011, 2018. (link)
Burkel, B. and Notbohm, J. Mechanical response of collagen networks to nonuniform microscale loads. Soft Matter, 13:5749-5758, 2017. (link)
Owen, L. M., Adhikari, A. S., Patel, M., Grimmer, P., Leijnse, N., Kim, M. C., Notbohm, J., Franck, C., and Dunn, A. R. A cytoskeletal clutch mediates cellular force transmission in a soft, 3D extracellular matrix. Mol Biol Cell, 28, 1959-1974, 2017. (link)
Jang, H., Notbohm, J., Gweon, B., Cho, Y., Park, C. Y., Kee, S.-H., Fredberg, J. J., Shin, J. H., and Park, Y. Homogenizing cellular tension by hepatocyte growth factor in expanding epithelial monolayer. Sci Rep, 7:45844, 2017. (link)
Notbohm, J., Banerjee, S., Utuje, K. J., Gweon, B., Jang, H., Park, Y., Shin, J., Butler, J. P., Fredberg, J. J., and Marchetti, M. C. Cellular contraction and polarization drive collective cellular motion. Biophys J, 110(12):2729–2738, 2016. (link)
Rosakis, P., Notbohm, J., and Ravichandran, G. A model for compression-weakening materials and the elastic fields due to contractile cells. J Mech Phys Solids, 85:18–32, 2015. (link)
Park, J.-A., Kim, J. H., Bi, D., Mitchel, J. A., Qazvini, N. T., Tantisira, K., Park, C. Y., McGill, M., Kim, S.-H., Gweon, B., Notbohm, J., Steward Jr., R., Burger, S., Randell, S. H., Kho, A. T., Tambe, D. T., Hardin, C., Shore, S. A., Israel, E., Weitz, D. A., Tschumperlin, D. J., Henske, E. P., Weiss, S. T., Manning, M. L., Butler, J. P., Drazen, J. M., and Fredberg, J. J. Unjamming and cell shape in the asthmatic airway epithelium. Nat Mater, 14:1040–1048, 2015. (link)
Notbohm, J., Lesman, A., Tirrell, D. A., and Ravichandran, G. Quantifying cell-induced matrix deformation in three dimensions based on imaging matrix fibers. Integr Biol, 7(10):1186–1195, 2015. (link)
Notbohm, J., Lesman, A., Rosakis, P., Tirrell, D. A., and Ravichandran, G. Microbuckling of fibrin provides a mechanism for cell mechanosensing. J R Soc Interface, 12(108):20150320, 2015. (link)
Lesman, A., Notbohm, J., Tirrell, D., and Ravichandran, G. Contractile forces regulate cell division in three-dimensional environments. J Cell Biol, 205(2):155–162, 2014. (link)
Notbohm, J., Rosakis, A., Kumagai, S., Xia, S., and Ravichandran, G. Three-dimensional displacement and shape measurement with a diffraction-assisted grid method. Strain, 49(5):399–408, 2013. (link)
Notbohm, J., Kim, J. H., Asthagiri, A. R., and Ravichandran, G. Three-dimensional analysis of the effect of epidermal growth factor on cell-cell adhesion in epithelial cell clusters. Biophys J, 102(6):1323–1330, 2012. (link)
Notbohm, J., Poon, B., and Ravichandran, G. Analysis of nanoindentation of soft materials with an atomic force microscope. J Mater Res, 27(1):229–237, 2012. (link)
Liu, J., Notbohm, J. K., Carpick, R. W., and Turner, K. T. Method for characterizing nanoscale wear of atomic force microscope tips. ACS Nano, 4(7):3763–3772, 2010. (link)
Liu, J., Grierson, D. S., Moldovan, N., Notbohm, J., Li, S., Jaroenapibal, P., O’Connor, S. D., Sumant, A., Neelakantan, N., Carlisle, J. A., Turner, K. T., and Carpick, R. W. Preventing nanoscale wear of atomic force microscopy tips through the use of monolithic ultrananocrystalline diamond probes. Small, 6(10):1140–1149, 2010. (link)